Good gram-positive activity with increasing gram-negative activity with second- and third-generation cephalosporinsĮffective against Rickettsia, Mycoplasma and ChlamydiaĪctivity against gram-positive aerobic and anaerobic bacteriaĪctivity against Mycoplasma and ChlamydiaĮxamples are azithromycin, lincomycin, and clindamycin Good gram-positive activity with some gram-negative activity of the aminopenicillinsĬombined with clavulanic acid to inhibit beta-lactamase Antibiotics act against bacteria by interfering with either cell wall synthesis, nucleic acid synthesis, or protein synthesis. They may also be classified as bactericidal or bacteriostatic drugs. In this presentation the groups of antibiotics will be discussed and their rational use will be addressed.Īntibiotic Groups and Mechanism of ActionĪntibiotics can be classified according to their activity against gram-negative and/or gram-positive bacteria, as well as activity against aerobic and anaerobic bacteria. 1 Antibacterials are one of the most commonly used groups of drugs in veterinary medicine and the development of bacterial resistance to these drugs is of grave concern to both animal and human health. All antibiotics are bacteriostatic, which means that at suitable concentrations they inhibit bacterial growth, and some antibiotics are bactericidal, which means that they are able to destroy bacteria when conditions are suitable. 1 The sulphonamides are synthetic organic materials and, in the true sense of the word, are classified as antibacterials rather than antibiotics. Antibiotics are a complex group of organic chemicals produced by microorganisms that have a detrimental effect on other organisms.
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